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Objective: To determine the prevalence and risk factors associated with SARS-CoV-2 infection among workers of Instituto Nacional de Salud del Nino (INSN) from April 2020 to March 2021. Material(s) and Method(s): A non-experimental, descriptive, cross-sectional study. The sample consisted of 608 workers who tested positive for COVID-19 using a rapid antigen test. The COVID-19 clinical-epidemiological research sheets prepared by the Ministry of Health of Peru and self-administered by the workers were reviewed. The INSN Department of Epidemiology staff verified the completion of the sheets. The data was entered into a database, which was used for the respective statistical analysis. The study was approved by the INSN Institutional Research Ethics Committee (registration code: PI-17/21). Result(s): COVID-19 prevalence among INSN workers was 7.24 % from April 2020 to March 2021. Out of the workers with COVID-19, 71.4 % were women;83.4 % were in the 30 to 59 age range with an average age of 44.71 years;65.6 % were healthcare workers, most of whom were nursing technicians;and 56.9 % experienced symptoms, mainly fever/chills (12.2 %), cough (8.9 %), malaise (7.7 %), sore throat (6.7 %), stuffy nose (2.5 %) and headache (1.3 %). Most workers lived in Lima Centro districts (33.2 %). A significant association between sex, age groups, worker type and worker profile was found. Conclusion(s): COVID-19 prevalence among INSN workers was 7.24 %;the most frequent characteristics, which showed significant differences with the rest of the factors, were being a woman, healthcare worker and nursing technician. A total of 56.9 % of the workers experienced symptoms, only 20.9 % developed clinical signs and 10.9 % had comorbidities.Copyright © La revista. Publicado por la Universidad de San Martin de Porres, Peru.
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Epidemiological data is the data obtained based on disease, injury or environmental hazard occurrence using the previous data on the epidemic situation. We can use it for analysis and find the trends and patterns. We can use different machine learning models to create a platform that can be used for different time series data. We can rely on the properties of time series data like trends and seasonality and use this for future prediction. Acquiring the dataset is the first step in data preprocessing in machine learning. We have collected the dataset from ourWorldIndia website which is a real-life dataset of covid-19. This paper presents the idea of a dedicated machine learning model to forecast the future using epidemiological data. We have taken a data-set of covid-19 for the prediction of the number of daily cases infected by the coronavirus. Our machine learning model can be applied on the dataset of any country in the world. We have applied it on the dataset of India in the experimentation. Our goal behind this research paper is to give the ML model which can be easily used on any epidemiological data for prediction by analysing the seasonality.
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Objective: To describe the epidemiological and clinical profile of pediatric patients who were treated for suspected COVID-19 infecion, between March and October 2020, at the Hospital Universitario San Ignacio (HUSI), in Bogota, Colombia. Material(s) and Method(s): Cross-sectional design. Description of patients aged 1 month to 1 day before their 18th birthday, assessed between March and October 2020, who were approached by any pediatric care service of a university hospital for suspected COVID-infection. 19, according to current national and institutional protocols. Demographic variables and the reason for consultation of all individuals with suspected infection were recorded. Only when SARS-CoV-2 infection was confirmed were variables related to clinical aspects of the disease and its evolution recorded. Result(s): 920 medical records of pediatric patients with suspected SARS-CoV-2 infection were evaluated, of which there were 157 confirmed cases with COVID-19 infection. The main reason for consultation to suspect infection was fever in 50% of the cases. In patients with virological confirmation, 32.48% of the cases attended required hospital management. MIS-C was suspected in 5 patients who required intensive care unit management. In the evaluated period, there were no deaths associated with COVID-19 infection. Conclusion(s): SARS-CoV-2 infection is related in most cases to a spectrum of mild disease in the pediatric population. This study may be larger than pediatric patients presenting with gastrointestinal rather than respiratory symptoms, and the frequency of renal complications should be taken into account in patients in whom the systemic inflammatory syndrome associated with COVID-19 is suspected.Copyright © 2023 Asociacion Colombiana de Infectologia. All rights reserved.
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The global outbreak of the new coronavirus infection COVID-19 is still ongoing, leading to coinfections such as malaria and COVID-19 and others. As evidenced, by the increase in various reports of coinfections. In recent years, Uzbekistan has achieved epidemiological stability for malaria and in 2018 received, an official World Health Organization certificate confirming the country's "malaria-free" status. At the present stage during the COVID-19 pandemic, imported, malaria from abroad, is relevant for our republic and, therefore, there is a constant danger of renewed, transmission, from imported cases. In this article presented the clinical case of coinfection, of COVID-19 and. malaria in a patient. From, the epidemiological data, the patient was a citizen of Cameroon. During treatment of coronavirus infection, the patient noted intermittent chills all over the body and sweating, clinical symptoms of tropical malaria began to appear. Microscopy of a thick drop and. a thin blood, smear confirmed, the presence of Pl. falciparum.. The patient was prescribed, antimalarial therapy with mefloquine, resulting in clinical recovery.Copyright © 2022 Authors. All rights reserved.
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The article discusses the issues of terminology, epidemiology, etiopathogenesis, clinical manifestations, approaches to the diagnosis and treatment of post-covid syndrome (PCS). It has been shown that the incidence of PCS in people who had COVID-19 is 10-35%;there are no generally accepted approaches to defining the term PCS. Clinical manifestations of PCS include more than 50 symptoms that occur in both children and adults, regardless of their place of residence. The damage caused by metabolites of the systemic inflammatory response of the central nervous system with the formation of a syndrome of autonomic dysfunction, cognitive impairment, and affective disorders is of critical importance in the genesis of PCS. Antipsychotics, antidepressants, and benzodiazepine drugs are used in the correction of PCS. However, they have limitations, in particular - when used in children with comorbid disorders. The use of aminoacetic acid (glycine), which has a wide range of safety, anxiolytic, anti-inflammatory, and nootropic effects in the correction of PCS, can become an effective therapeutic strategy.Copyright © Team of Authors, 2022.
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The purposes of this review was in the direction of epidemiology, causative agents, symptoms, vaccine research probabilities and COVID-19 infection novel Corona viruses that was investigated in China. The COVID-19 has surrounded viruses along with a practical sensation one stranded RNA genome and a nucleocapsid of helical uniformity. The COVID-19 is an enormous family of viruses that are prevalent in a public and large number of species of animals including hens, camels, bats, cat, and cattle. Human corona viruses can cause gentle disorder identical to a common cough, cold, while others reason more acute disease MERS (Middle East Respiratory Syndrome) and SARS (Severe Acute Respiratory Syndrome). Thus spreading the COVID-19 should be closely investigated to recognize the growth of particularly virulent strains in society at an early stage and to simplify the evolution of enough preventive and therapeutic measurements.Copyright © 2021, Health Biotechnology and Biopharma. All rights reserved.
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Mechanical ventilation (MV) is a life-support therapy that may predispose to morbid and lethal complications, with ventilator-associated pneumonia (VAP) being the most prevalent. In 2013, the Center for Disease Control (CDC) defined criteria for ventilator-associated events (VAE). Ten years later, a growing number of studies assessing or validating its clinical applicability and the potential benefits of its inclusion have been published. Surveillance with VAE criteria is retrospective and the focus is often on a subset of patients with higher than lower severity. To date, it is estimated that around 30% of ventilated patients in the intensive care unit (ICU) develop VAE. While surveillance enhances the detection of infectious and non-infectious MV-related complications that are severe enough to impact the patient's outcomes, there are still many gaps in its classification and management. In this review, we provide an update by discussing VAE etiologies, epidemiology, and classification. Preventive strategies on optimizing ventilation, sedative and neuromuscular blockade therapy, and restrictive fluid management are warranted. An ideal VAE bundle is likely to minimize the period of intubation. We believe that it is time to progress from just surveillance to clinical care. Therefore, with this review, we have aimed to provide a roadmap for future research on the subject.Copyright © 2022 The Author(s)
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Over the last decade, the introduction of new antifungal drugs and diagnostic procedures has improved the prognosis of hematological patients with invasive fungal disease (IFD), primarily invasive aspergillosis. Despite effective antifungal prophylaxis against the most common IFD caused by Aspergillus spp., rates of IFD due to rare pathogens being resistant to most antifungal drugs, including mucormycosis have been increased. The main group of patients having a high risk of mucormycosis is deeply immunocompromised patients who received chemotherapy for acute leukemia, patients undergoing allogeneic bone marrow transplantation, or treated with corticosteroids for graft-versushost disease. Currently, the urgency of this complication is significantly higher due to COVID-19 pandemic and extensive use of corticosteroids for the treatment of COVID-19. Despite the fact that the criteria for the diagnosis of IFD EORTC/MSG 2008 and 2020 have been developed and implemented into practice in most countries, mucormycosis still remains a difficult-to-diagnose IFD, where the factor of rapid diagnosis is a main factor of treatment success. Medications available for the treatment of IFD include polyenes, triazoles, and echinocandins. For a long time, the drug of choice for the treatment of mucormycosis was liposomal amphotericin B. However, a new effective drug has been approved for the treatment of both mucormycosis and IFD, caused by multiple pathogens - isavuconazole. This review presents new data on the epidemiology of mucormycosis, diagnosis approaches and current international treatment guidelines.Copyright © 2021, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy. All rights reserved.
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Atrial fibrillation (AF) is the most frequent form of cardiac arrhythmia in COVID-19 infected patients. The occurrence of AF paroxysms is often associated with the acute period of infection in time. At the same time, the pathophysiological mechanisms of the occurrence of AF associated with COVID-19 remain insufficiently studied. The review considers the available literature data on the influence of factors such as reduced availability of angiotensin-converting enzyme 2 receptors, interaction of the virus with the cluster of differentiation 147 and sialic acid, increased inflammatory signaling, "cytokine storm", direct viral damage to the endothelium, electrolyte and acid-alkaline balance in the acute phase of severe illness and increased sympathetic activity.Copyright © Autors 2023.
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Since the outbreak of COVID-19, SARS-CoV-2 has continued to evolve. As the fifth variants of concern (VOCs) announced by the World Health Organization, Omicron has significantly changed from previous VOCs in terms of genome, biological and epidemiological characteristics. Although the severe illness and mortality caused by Omicron infection are significantly lower than those caused by the previous VOCs, Omicron's strong transmission ability has continued to break through the epidemic prevention barrier and human immunity barrier established by prior infections and vaccines. Omicron has opened a new chapter in the COVID-19 pandemic. In this paper, we review the changes in genome and biological characteristics of Omicron and its subspecies as well as the differences in epidemiological characteristics between Omicron and influenza viruses in order to provide scientific basis for the optimization of epidemic prevention and control.Copyright © 2023, Peking Union Medical College Hospital. All rights reserved.
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Background: The current United Nations sustainable development goal 3 sets to reduce maternal mortality to less than 70 per 100 000 live births by 2030. To monitor whether India is on track to attaining sustainable development goals, it is essential to routinely assess trends of health indicators. Objective(s): This study was conducted to assess trends of maternal mortality and cause-specific maternal death in tertiary care hospitals in Southern India. Method(s): This is a retrospective study of hospital records and death summaries of all maternal deaths between January 1, 2009, and December 31, 2018, at the tertiary care hospital in Southern India. The demographic, clinical, and delivery details of all the maternal deaths were collected. Causes of maternal deaths were classified as direct, indirect, and nonspecific. To observe trends of maternal death, the maternal mortality ratio was calculated for each year, and Pearson's chi-square test was used. Result(s): Maternal mortality ratio was 555/100000 and had a decreasing trend from its highest in 2010 of 1230/100000 to its lowest of 229/100000 in 2017 (t = 7.71 p = 0.02). The majority of women who died were aged 21-35 years, resided in rural, were primigravidae, and had operative delivery. Most of the maternal deaths had been referred to our facility (90.8%) from other healthcare units. Obstetric hemorrhage (27.8%) and puerperal sepsis (37.7%) among direct causes;H1N1 pneumonia (34.8%) among indirect causes were the major causes of maternal death. The number of maternal deaths due to sepsis increased from the beginning until the end of the study from 10% to 50% (t = 5.9, p = 0.01). On the contrary, there was a decline in maternal deaths due to obstetric hemorrhage from 50% to 25% (t = 4.2, p = 0.03). Conclusion(s): Although the maternal mortality ratio has reduced over the years, sepsis was an important cause of maternal deaths.Copyright © 2023 Bentham Science Publishers.
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Due to the increasing availability and openness of data from many countries worldwide, visualizations of the COVID-19 pandemic that aim to track the virus over time and across geographic areas are multiplying;geovisualization is proving to be an effective solution to better understand the spread of SARS-CoV-2. However, due to the resulting "infodemic,” many visualization approaches are sub-optimal. For example, direct projections of COVID-19-related data on display are unsound from a cartographic point of view;the results are often overcomplicated, leading to cognitive overload, which may in turn, lead to misinterpretations. Thus, developing effective geovisualization methods is necessary to improve epidemiologists' and local authorities' decision-making abilities. This study proposes a novel approach to geovisualizing COVID-19-related data based on chorems. Our objective was to define a chorematic map that could represent, through visual summaries extracted from the analysis of COVID-19-related data, the origin of the first cases and evolution of the virus in Algeria during the first months of the pandemic. Accordingly, we propose a geovisualization methodology based on spatial data mining techniques and GIS technology. © 2023 Cartography and Geographic Information Society.
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A clinical case of a combined course of leptospirosis and coronavirus infection in a 71-year-old patient is presented. One of the features of this case was the difficulty of confirming the clinical diagnosis of leptospirosis in the absence of a typical clinical picture of this disease. Only the data of the epidemiological history and manifestations of the disease atypical for coronavirus infection allowed to suspect leptospirosis and confirm it by methods of specific laboratory diagnostics. The stages of differential diagnostic search in the practice of an infectious disease doctor are described.Copyright © 2022 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.
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A clinical case of a combined course of leptospirosis and coronavirus infection in a 71-year-old patient is presented. One of the features of this case was the difficulty of confirming the clinical diagnosis of leptospirosis in the absence of a typical clinical picture of this disease. Only the data of the epidemiological history and manifestations of the disease atypical for coronavirus infection allowed to suspect leptospirosis and confirm it by methods of specific laboratory diagnostics. The stages of differential diagnostic search in the practice of an infectious disease doctor are described.Copyright © 2022 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.
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The aim of the study. To analyze formation features of the epidemic situation for tuberculosis (TB) in the context of the COVID-19 pandemic in order to predict the further actions of medical organizations. Materials and methods. The data for the region for the last 5 years (2017-2021) were analyzed, including 1,762 newly diagnosed cases of patients with TB and comorbidities (according to the data of the Regional Public Health Organization <<Regional Clinical Anti-Tuberculosis Dispensary>>). All cases were verified using standard diagnostic methods, including molecular genetic methods, to determine the resistance of pathogens to antibacterial drugs. Results. It was revealed that the epidemiological situation in the region was multidirectional: thus, during the COVID-19 epidemic, the most pronounced incidence decrease was observed among cases of chronic course hepatitis (by 16.4 times), while among patients with tuberculosis the incidence decreased by 2.75 times, and among patients with acute hepatitis - only by 1.5 times (P<0.05). Among the cases of comorbid infection, the most severe course was observed in patients with combined (TB + HIV) infection: there was both a more severe general condition, and the development of adverse (undesirable) reactions to anti-TB drugs, which required an extension of maintenance therapy. Conclusions. The results of the study showed that against the background of the COVID-19 pandemic in the region, there was no tendency towards a worsening of the epidemic situation, primarily for the more socially significant infection - tuberculosis. At the same time, there was an increase in the number of cases of comorbid pathology, including HIV + TB. In the treatment of patients with comorbid forms of infection, it is necessary to take into account the possibility of developing hepatotoxic reactions and, as a result, the appointment of accompanying drugs with hepatoprotective and detoxification effects in therapy.Copyright © Team of Authors, 2022.
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Coronavirus disease 2019 (COVID-19) is an acute infectious disease of the respiratory system caused by the new coronavirus 2 (SARS-CoV-2). COVID-19 affects children of all ages, even newborns and children under one year. There are no reliable data on risk factors of SARS-CoV-2 infection in children, although family cases are well documented. Most children have a mild clinical course with common symptoms such as fever, cough, fatigue, myalgia, vomiting, and diarrhea. Elevated markers of inflammation and radiological changes are less common and pronounced than in adults. There are no reliable data on the relationship between aggravating comorbid conditions in children and the severity of COVID-19.Copyright © 2021, Professionalnye Izdaniya. All rights reserved.
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Coronavirus disease 2019 (COVID-19) is an acute infectious disease of the respiratory system caused by the new coronavirus 2 (SARS-CoV-2). COVID-19 affects children of all ages, even newborns and children under one year. There are no reliable data on risk factors of SARS-CoV-2 infection in children, although family cases are well documented. Most children have a mild clinical course with common symptoms such as fever, cough, fatigue, myalgia, vomiting, and diarrhea. Elevated markers of inflammation and radiological changes are less common and pronounced than in adults. There are no reliable data on the relationship between aggravating comorbid conditions in children and the severity of COVID-19.Copyright © 2021, Professionalnye Izdaniya. All rights reserved.
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Introduction. The quality and availability of medical care for children of country depends on the quantity of pediatricians and the quality of their training. This is especially important in the context of the COVID-19 pandemic. Purpose. To assess the state of staffing and training of pediatricians in healthcare institutions of Ukraine in comparison with same world and European indicators and determine the necessary measures for improvement. Materials and methods. For this research we have used methods of the system approach and epidemiological analysis of data from GU "Center of medical statistics of the Ministry of Health of Ukraine" for eleven years (2009-2020). Results. According to the level of training of doctors, including pediatricians, Ukraine has reached total rank of 38th in the European region. Such dynamics of changes in the availability of human resources for healthcare is accompanied by reductions in the volume of training of pediatricians since 2017. According to the Center for Medical Statistics from 31.12.2020 the Ministry of Health of Ukraine provided medical care in pediatric health care institutions of all forms of ownership with the help of 8812 pediatricians, of whom 7925 (90%) were worked in primary health care centers, clinics and hospitals of the Ministry of Health of Ukraine. This numbers are significantly lower than in 2009, when there were 12 450 practicing pediatricians. As we see, the number of pediatricians has decreased by 15.4% for the last 7 years. Conclusion. Importance of the problems with personnel in pediatric healthcare had shown us a necessity of radical government management decisions for improvement of the situation with the training of pediatricians and preventing of risks of limitations of access to pediatric medical assistance and deterioration of quality of medical care for children in the country. This might be possible with rational planning of the state necessity in the training of pediatricians and significant improvement of their social protection and working conditions. Possible steps should include increasing pediatrics necessity state order up to 1000 pediatricians in state medical universities annually by targeted regional medical personnel necessity order, taking into account the needs of the regions and reviewing their training programs in accordance with the modern requirements.Copyright © 2022, Professionalnye Izdaniya. All rights reserved.